Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect

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Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect

This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a "good person," who stole from the ri...

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Sodium-Glucose Cotransporter-2 Inhibition and the Glomerulus: A Review

UNLABELLED Blood glucose-lowering treatment options generally target insulin action or beta-cell function. In diabetes, expression of the sodium-glucose cotransporter-2 (SGLT2) genes is up-regulated and renal threshold increased, resulting in increased glucose reabsorption from glomerular filtrate, reducing urinary glucose excretion and worsening the hyperglycemic condition. The SGLT2 inhibitor...

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Energy Balance After Sodium–Glucose Cotransporter 2 Inhibition

OBJECTIVE Sodium-glucose cotransporter 2 (SGLT2) inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria. Our aim was to analyze this phenomenon quantitatively. RESEARCH DESIGN AND METHODS Eighty-six patients with type 2 diabetes (HbA1c 7.8 ± 0.8% [62 ± 9 mmol/mol], estimated glomerular filtration rate [eGFR] 89 ± 19 mL ⋅ min(-1) ⋅ 1.73 m(-2)) rec...

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Energy Balance After Sodium Glucose Cotransporter 2 (SGLT2) Inhibition

Eighty-six patients with type 2 diabetes (HbA1c = 7.86 0.8% [62 6 9 mmol/mol], estimated glomerular filtration rate [eGFR] = 89 6 19 mL · min · 1.73 m) received empagliflozin (25 mg/day) for 90 weeks with frequent (n = 11) assessments of body weight, eGFR, and fasting plasma glucose (FPG). Time-dependent glucose filtration was calculated as the product of eGFR and FPG; time-dependent glycosuria...

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The effect of sodium/glucose cotransporter 2 (SGLT2) inhibition on the urinary proteome

Treatment with empagliflozin, an inhibitor of the sodium/glucose cotransporter 2 (SGLT2), is associated with slower progression of diabetic kidney disease. In this analysis, we explored the hypothesis that empagliflozin may have an impact on urinary peptides associated with chronic kidney disease (CKD). In this post-hoc, exploratory analysis, we investigated urine samples obtained from 40 patie...

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ژورنال

عنوان ژورنال: Indian Journal of Endocrinology and Metabolism

سال: 2016

ISSN: 2230-8210

DOI: 10.4103/2230-8210.183826